Memory. Engram cells retain memory under retrograde amnesia
- PMID: 26023136
- PMCID: PMC5583719
- DOI: 10.1126/science.aaa5542
Memory. Engram cells retain memory under retrograde amnesia
Abstract
Memory consolidation is the process by which a newly formed and unstable memory transforms into a stable long-term memory. It is unknown whether the process of memory consolidation occurs exclusively through the stabilization of memory engrams. By using learning-dependent cell labeling, we identified an increase of synaptic strength and dendritic spine density specifically in consolidated memory engram cells. Although these properties are lacking in engram cells under protein synthesis inhibitor-induced amnesia, direct optogenetic activation of these cells results in memory retrieval, and this correlates with retained engram cell-specific connectivity. We propose that a specific pattern of connectivity of engram cells may be crucial for memory information storage and that strengthened synapses in these cells critically contribute to the memory retrieval process.
Copyright © 2015, American Association for the Advancement of Science.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5583719/bin/nihms900165f1.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5583719/bin/nihms900165f2.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5583719/bin/nihms900165f3.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5583719/bin/nihms900165f4.gif)
Similar articles
-
Silent memory engrams as the basis for retrograde amnesia.Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9972-E9979. doi: 10.1073/pnas.1714248114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078397 Free PMC article.
-
Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease.Nature. 2016 Mar 24;531(7595):508-12. doi: 10.1038/nature17172. Epub 2016 Mar 16. Nature. 2016. PMID: 26982728 Free PMC article.
-
Synapse-specific representation of the identity of overlapping memory engrams.Science. 2018 Jun 15;360(6394):1227-1231. doi: 10.1126/science.aat3810. Science. 2018. PMID: 29903972
-
Memory engram storage and retrieval.Curr Opin Neurobiol. 2015 Dec;35:101-9. doi: 10.1016/j.conb.2015.07.009. Epub 2015 Aug 14. Curr Opin Neurobiol. 2015. PMID: 26280931 Review.
-
A Synaptic Framework for the Persistence of Memory Engrams.Front Synaptic Neurosci. 2021 Mar 24;13:661476. doi: 10.3389/fnsyn.2021.661476. eCollection 2021. Front Synaptic Neurosci. 2021. PMID: 33841124 Free PMC article. Review.
Cited by
-
Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum.Nat Commun. 2024 May 31;15(1):4645. doi: 10.1038/s41467-024-48373-3. Nat Commun. 2024. PMID: 38821918 Free PMC article.
-
Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations.Neuropsychopharmacology. 2024 Jul;49(8):1296-1308. doi: 10.1038/s41386-024-01825-2. Epub 2024 Mar 7. Neuropsychopharmacology. 2024. PMID: 38454052 Free PMC article.
-
Excitability mediates allocation of pre-configured ensembles to a hippocampal engram supporting contextual conditioned threat in mice.Neuron. 2024 May 1;112(9):1487-1497.e6. doi: 10.1016/j.neuron.2024.02.007. Epub 2024 Mar 5. Neuron. 2024. PMID: 38447576
-
Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus.Front Mol Neurosci. 2024 Feb 5;17:1342622. doi: 10.3389/fnmol.2024.1342622. eCollection 2024. Front Mol Neurosci. 2024. PMID: 38375501 Free PMC article. Review.
-
Neuronal ensembles: Building blocks of neural circuits.Neuron. 2024 Mar 20;112(6):875-892. doi: 10.1016/j.neuron.2023.12.008. Epub 2024 Jan 22. Neuron. 2024. PMID: 38262413 Review.
References
-
- Müller GE, Pilzecker A. Z Psychol SI. 1900;1
-
- Duncan CP. J Comp Physiol Psychol. 1949 Feb;42:32. - PubMed
-
- McGaugh JL. Science. 2000 Jan 14;287:248. - PubMed
-
- Flexner JB, Flexner LB, Stellar E. Science. 1963 Jul 5;141:57. - PubMed
-
- Flexner LB, Flexner JB, Roberts RB. Science. 1967 Mar 17;155:1377. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources