Emerging targets in neuroinflammation-driven chronic pain
- PMID: 24948120
- PMCID: PMC4228377
- DOI: 10.1038/nrd4334
Emerging targets in neuroinflammation-driven chronic pain
Abstract
Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role in the induction and maintenance of chronic pain. This Review focuses on emerging targets - such as chemokines, proteases and the WNT pathway - that promote spinal cord neuroinflammation and chronic pain. It also highlights the anti-inflammatory and pro-resolution lipid mediators that act on immune cells, glial cells and neurons to resolve neuroinflammation, synaptic plasticity and pain. Targeting excessive neuroinflammation could offer new therapeutic opportunities for chronic pain and related neurological and psychiatric disorders.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4228377/bin/nihms640004f1.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4228377/bin/nihms640004f2.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4228377/bin/nihms640004f3.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4228377/bin/nihms640004f4.gif)
Similar articles
-
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.Anesthesiology. 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130. Anesthesiology. 2018. PMID: 29462012 Free PMC article. Review.
-
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential.Pharmacol Ther. 2020 Aug;212:107581. doi: 10.1016/j.pharmthera.2020.107581. Epub 2020 May 22. Pharmacol Ther. 2020. PMID: 32450191 Review.
-
Perspectives in Pain Research 2014: Neuroinflammation and glial cell activation: The cause of transition from acute to chronic pain?Scand J Pain. 2015 Jan 1;6(1):3-6. doi: 10.1016/j.sjpain.2014.10.002. Scand J Pain. 2015. PMID: 29911589
-
Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis.Pain Physician. 2016 Feb;19(2):11-24. Pain Physician. 2016. PMID: 26815246
-
Pain that won't quit.Sci Am. 2014 Dec;311(6):60-5, 67. doi: 10.1038/scientificamerican1214-60. Sci Am. 2014. PMID: 25518629 No abstract available.
Cited by
-
Exploring the safety of lycorine in the central nervous system and its impact on pain-like behaviors in mice.Sci Rep. 2024 Jul 22;14(1):16856. doi: 10.1038/s41598-024-64410-z. Sci Rep. 2024. PMID: 39039158
-
[6]-Shogaol and [6]-Gingerol active ingredients may improve neuropathic pain by suppressing cytokine levels in an experimental model.Turk J Med Sci. 2023 Oct 31;53(6):1593-1604. doi: 10.55730/1300-0144.5728. eCollection 2023. Turk J Med Sci. 2023. PMID: 38813490 Free PMC article.
-
Electroacupuncture improves allodynia and central sensitization via modulation of microglial activation associated P2X4R and inflammation in a rat model of migraine.Mol Pain. 2024 Jan-Dec;20:17448069241258113. doi: 10.1177/17448069241258113. Mol Pain. 2024. PMID: 38744426 Free PMC article.
-
Synthesis, molecular docking evaluation for LOX and COX-2 inhibition and determination of in-vivo analgesic potentials of aurone derivatives.Heliyon. 2024 Apr 20;10(9):e29658. doi: 10.1016/j.heliyon.2024.e29658. eCollection 2024 May 15. Heliyon. 2024. PMID: 38694111 Free PMC article.
-
PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief.Cell Biosci. 2024 Apr 20;14(1):51. doi: 10.1186/s13578-024-01227-3. Cell Biosci. 2024. PMID: 38643205 Free PMC article. Review.
References
-
- Johannes CB, Le TK, Zhou X, Johnston JA, Dworkin RH. The prevalence of chronic pain in United States adults: results of an Internet-based survey. J Pain. 2010;11:1230–1239. - PubMed
-
- Stein C, Millan MJ, Herz A. Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds. Pharmacol Biochem Behav. 1988;31:455–51. - PubMed
-
- Honore P, et al. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience. 2000;98:585–598. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical