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Population genetics is the study of the genetic composition of populations, including distributions and changes in genotype and phenotype frequency in response to the processes of natural selection, genetic drift, mutation and gene flow.
Desiccation tolerance evolved multiple times across the land plants for survival in water-limited habitats. We find that desiccation tolerance evolved convergently in grasses by independent duplication of the same gene family and activation of conserved, ancestral protective pathways.
Two groups of scientists independently engineer gene drives in Arabidopsis thaliana, demonstrating the possibility for spreading fitness-reducing genetic modifications through wild populations of plants for population suppression.
GeneBayes is a Bayesian approach incorporating a Wright–Fisher population model with machine learning of gene features to infer an interpretable gene constraint metric that has a broad range of uses in downstream analysis.
Representation Learning for Genetic Discovery on Low-Dimensional Embeddings (REGLE) uses machine learning to generate low-dimensional representations of healthcare data. Applied to lung spirograms and blood volume photoplethysmograms, REGLE factors capture additional information beyond expert-defined features, suggesting the utility of this approach.
In this study, the authors retrieve frozen stocks of the K. lactis lineages and reconstruct the evolutionary dynamics of parallel lineages at the genetic level with high throughput sequencing
Desiccation tolerance evolved multiple times across the land plants for survival in water-limited habitats. We find that desiccation tolerance evolved convergently in grasses by independent duplication of the same gene family and activation of conserved, ancestral protective pathways.
Petrazzini et al. leverage exome sequencing data and a novel machine learning-based marker to identify rare and ultra-rare coding variants associated with coronary artery disease.
Two groups of scientists independently engineer gene drives in Arabidopsis thaliana, demonstrating the possibility for spreading fitness-reducing genetic modifications through wild populations of plants for population suppression.