CASTLE, a deep learning approach, extracts interpretable discrete representations from single-cell chromatin accessibility data, enabling accurate cell type identification, effective data integration, and quantitative insights into gene regulatory mechanisms.
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Wei, Z. Discrete latent embeddings illuminate cellular diversity in single-cell epigenomics. Nat Comput Sci 4, 316–317 (2024). https://doi.org/10.1038/s43588-024-00634-3
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DOI: https://doi.org/10.1038/s43588-024-00634-3
