An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreased expression of the selenoprotein GPX4, a master regulator of ferroptosis, and induced ferroptosis. Mechanistically, PRDX6 increases the efficiency of selenium use by acting as a selenium delivery protein.
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This is a summary of: Fujita, H. et al. PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01329-z (2024).
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Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01330-6
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DOI: https://doi.org/10.1038/s41594-024-01330-6
