A major bottleneck of targeted protein degradation (TPD) has been the discovery of E3 ligases that are amenable to this strategy. Two new studies highlight the potential of FBXO22 as a candidate for TPD, thus expanding the toolbox of hijackable ligases.
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Acknowledgements
M.K.’s work is partly supported by the National Cancer Institute Grant Number T32CA236754.
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M.K. is a paid consultant for Life Science Editors. C.J. declares no competing interests.
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Jin, C., Kostic, M. F-boxing substrates away. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01666-6
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DOI: https://doi.org/10.1038/s41589-024-01666-6
