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Lipid metabolism

All roads lead to OSBP

Nature Chemical Biology (2024)Cite this article

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Natural products and synthetic bifunctional molecules enable the development of new chemical probes that target oxysterol-binding protein (OSBP), a key player in intracellular cholesterol homeostasis and Golgi complex integrity and a potential target for metabolic disease and cancer.

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Fig. 1: Two classes of small molecules inhibit OSBP but exhibit different phenotypic effects.

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Authors and Affiliations

  1. Department of Chemistry & Chemical Biology, Cornell University, Ithaca, NY, USA

    Po-Hsun Brian Chen & Jeremy M. Baskin

  2. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA

    Po-Hsun Brian Chen & Jeremy M. Baskin

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  1. Po-Hsun Brian Chen
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  2. Jeremy M. Baskin
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Correspondence to Jeremy M. Baskin.

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The authors declare no competing interests.

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Chen, PH.B., Baskin, J.M. All roads lead to OSBP. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01639-9

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