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Transposable elements

LINE1 mediates long-range DNA interactions

Nature Genetics (2024)Cite this article

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The impact of transposable elements (TEs) on gene regulatory networks and how they are governed remain poorly understood. A new study identifies a role for LINE1, a specific subset of TEs, in the long-range regulation of gene expression, particularly during embryonic development.

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Fig. 1: Overview of the experimental outline and the temporal dynamics of LINE1 enhancer activity during ZGA.

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Acknowledgements

Work in the Wang laboratory is supported by NIH grants R01HG007175, U24ES026699, U01HG009391 and UM1DA058219.

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Authors and Affiliations

  1. Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA

    Yonghao Liang & Ting Wang

  2. Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, MO, USA

    Yonghao Liang & Ting Wang

  3. McDonnell Genome Institute, Washington University School of Medicine, Saint Louis, MO, USA

    Ting Wang

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  1. Yonghao Liang
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  2. Ting Wang
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Correspondence to Ting Wang.

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Liang, Y., Wang, T. LINE1 mediates long-range DNA interactions. Nat Genet (2024). https://doi.org/10.1038/s41588-024-01824-5

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  • DOI: https://doi.org/10.1038/s41588-024-01824-5

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