Extended Data Fig. 9: Stratification of patients with VHL disease by SGE function class.
From: Saturation genome editing maps the functional spectrum of pathogenic VHL alleles
![Extended Data Fig. 9](https://cdn.statically.io/img/media.springernature.com/full/springer-static/esm/art%3A10.1038%2Fs41588-024-01800-z/MediaObjects/41588_2024_1800_Fig15_ESM.jpg)
a, Patients in the Freiburg VHL Registry were grouped according to whether their germline VHL variant was functionally classified as LOF1 or LOF2 by SGE, and a Kaplan–Meier estimator was used to assess differences in age-related ccRCC penetrance with log-rank test for significance (additional details in Methods). b, The same analysis and log-rank test were repeated including only patients with variants not reported to be pathogenic in ClinVar at time of analysis (that is, absent, VUS or conflicting interpretations).