Extended Data Fig. 4: A map of RNA scores for n = 1,626 SNVs in VHL.
From: Saturation genome editing maps the functional spectrum of pathogenic VHL alleles
a, RNA scores, defined as each SNV’s abundance in cDNA normalized to its abundance in gDNA, are plotted by transcript position. RNA scores shown are from samples collected 6 days post-transfection. b, Day 6 RNA scores from individual replicates are highly correlated (Pearson’s R = 0.87). c, Comparison of function scores and RNA scores indicates that below an RNA score threshold of −3.0 (dashed line), 6 of 7 synonymous variants were significantly depleted.