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Healthy ageing and the kidney — lessons from centenarians

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Centenarians — who are a putative model of healthy longevity — often have a low risk of cardiovascular disease, despite an age-associated decline in kidney function. An understanding of the molecular and cellular underpinnings of health kidney ageing in centenarians may provide clues for the prevention or alleviation of the burden of kidney disease in older populations.

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Fig. 1: Proposed extent of structural and functional changes that occur the kidney in individuals with chronic kidney disease, in those who undergo normal ageing and in centenarians.

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Correspondence to Yasumichi Arai.

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M.Y. has received research grants from Mitsubishi Tanabe Pharma and Boehringer Ingelheim. Y.A. declares no competing interests.

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Arai, Y., Yanagita, M. Healthy ageing and the kidney — lessons from centenarians. Nat Rev Nephrol (2024). https://doi.org/10.1038/s41581-024-00860-y

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