BRCA1 and friends 30 years on

1. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66–71 (1994).

   Article  CAS  PubMed  Google Scholar 

2. Hall, J. M. et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684–1689 (1990).

   Article  CAS  PubMed  Google Scholar 

3. Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789–792 (1995).

   Article  CAS  PubMed  Google Scholar 

4. Moslehi, R. et al. BRCA1 and BRCA2 mutation analysis of 208 Ashkenazi Jewish women with ovarian cancer. Am. J. Hum.Genet. 66, 1259–1272 (2000).

   Article  CAS  PubMed  PubMed Central  Google Scholar 

5. Kuchenbaecker, K. B. et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. J. Am. Med. Assoc. 317, 2402–2416 (2017).

   Article  CAS  Google Scholar 

6. Foulkes, W. D. The ten genes for breast (and ovarian) cancer susceptibility. Nat. Rev. Clin. Oncol. 18, 259–260 (2021).

   Article  CAS  PubMed  Google Scholar 

7. Pharoah, P. D. et al. Polygenic susceptibility to breast cancer and implications for prevention. Nat. Genet. 31, 33–36 (2002).

   Article  CAS  PubMed  Google Scholar 

8. Tutt, A. N. J. et al. Adjuvant olaparib for patients with BRCA1- or BRCA2-mutated breast cancer. N. Engl. J. Med. 384, 2394–2405 (2021).

   Article  CAS  PubMed  PubMed Central  Google Scholar 

9. Manickam, K. et al. Exome sequencing-based screening for BRCA1/2 expected pathogenic variants among adult biobank participants. JAMA Netw. Open 1, e182140 (2018).

   Article  PubMed  PubMed Central  Google Scholar 

10. Hughley, R. et al. Etiologic index - a case-only measure of BRCA1/2-associated cancer risk. N. Engl. J. Med. 383, 286–288 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

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