Oocyte development involves the prolonged and intricate process of building a distinctive transcriptome and epigenome to anticipate embryogenesis after fertilization. Research now shows that mouse oocytes use an unusual chromatin signature to mark regulatory elements, and that the transcription factors TCF3 and TCF12 have a key role.
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References
Liu, B. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01422-x (2024).
Rada-Iglesias, A. et al. Nature 470, 279–283 (2011).
Dunham, I. et al. Nature 489, 57–74 (2012).
Pennacchio, L. A., Bickmore, W., Dean, A., Nobrega, M. A. & Bejerano, G. Nat. Rev. Genet. 14, 288–295 (2013).
Dahl, J. A. et al. Nature 537, 548–552 (2016).
Zhang, B. et al. Nature 537, 553–557 (2016).
Liu, X. et al. Nature 537, 558–562 (2016).
Benayoun, B. A. et al. Cell 158, 673–688 (2014).
Calo, E. & Wysocka, J. Mol. Cell 49, 825–837 (2013).
Inoue, A., Jiang, L., Lu, F., Suzuki, T. & Zhang, Y. Nature 547, 419–424 (2017).
Ishiuchi, T. et al. Nat. Struct. Mol. Biol. 28, 38–49 (2021).
Martire, S. et al. Nat. Genet. 51, 941–946 (2019).
Xia, W. et al. Science 365, 353–360 (2019).
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Cao, Q., Grow, E.J. TCF3, TCF12 and distinct enhancers regulate oocyte transcription. Nat Cell Biol 26, 847–848 (2024). https://doi.org/10.1038/s41556-024-01433-8
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DOI: https://doi.org/10.1038/s41556-024-01433-8