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Morbidity and neurodevelopmental outcomes at 2 years in preterm infants undergoing percutaneous transcatheter closure vs. surgical ligation of the PDA

Journal of Perinatology (2024)Cite this article

Subjects

Abstract

Objective

Review a cohort of preterm infants ≤29 weeks of gestation at birth and compare morbidities and neurodevelopmental outcomes based on PDA status and type of PDA closure.

Study design

Single center observational retrospective-prospective case control study of premature infants who had no hsPDA, underwent surgical ligation or percutaneous transcatheter closure of the PDA. Neurodevelopmental testing was done using the Bayley Scales of Infant Development 3rd ed.

Results

The percutaneous transcatheter closure group had an older post menstrual age and greater weight at the time of procedure, and started enteral feeds and achieved room air status at an earlier post procedure day. Infants in the surgical ligation group were more likely to experience vocal cord paralysis. There was no difference in neurodevelopmental outcomes between groups.

Conclusion

Waiting for infants to achieve the appropriate size for percutaneous transcatheter closure of the PDA may lead to reduced short-term complications without increasing the risk of neurodevelopmental impairment.

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Data availability

All data generated or analyzed during this study are included in this published article.

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Acknowledgements

We thank Westchester Medical Center and the High Risk Regional Neonatal Follow up Program associated with the NICU at Maria Fareri Children’s Hospital (MFCH) at Westchester Medical Center who allowed us to collect data for our study.

Author information

Authors and Affiliations

  1. Sunrise Children’s Hospital, Las Vegas, NV, USA

    Maria Cristina Fernandez

  2. The Regional Neonatal ICU Maria Fareri Children’s Hospital at Westchester Medical Center - New York Medical College Valhalla, Valhalla, NY, USA

    Maria Cristina Fernandez, Jordan S. Kase & Amy Reichlin

  3. Pediatric Cardiology Intervention, Maria Fareri Children’s Hospital at Westchester Medical Center-New York Medical College Valhalla, Valhalla, NY, USA

    Joseph Giamelli

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Contributions

MCF drafted the manuscript and performed the initial analysis. JK assisted with analysis, reviewed drafts of manuscripts and made substantial contributions to draft. JG contributed to the analysis plan and reviewed drafts of manuscripts and made contributions to draft. AR conceived the original project, scientific design, analysis plan, and reviewed and made contributions to multiple drafts of the paper. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

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Correspondence to Maria Cristina Fernandez.

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Fernandez, M.C., Kase, J.S., Giamelli, J. et al. Morbidity and neurodevelopmental outcomes at 2 years in preterm infants undergoing percutaneous transcatheter closure vs. surgical ligation of the PDA. J Perinatol (2024). https://doi.org/10.1038/s41372-024-02019-w

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