Geraldine Van der Auwera

Tewksbury, Massachusetts, United States Contact Info
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Activity

Publications

  • 12 peer-reviewed publications

    see PubMed

Projects

  • Genomics of anthrax-like Bacillus cereus megaplasmids

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    In the past decade, genome sequencing of clinical isolates of Bacillus cereus and Bacillus thuringiensis revealed the existence of plasmids that share extensive sequence conservation with large segments of the anthrax virulence plasmids pXO1 and pXO2. We recently found that up to 15% of environmental isolates of B. cereus sensu lato group organisms contain pXO1-like or pXO2-like plasmids as defined on the basis of conserved replicon sequences.

    We are now sequencing 96 environmental…

    In the past decade, genome sequencing of clinical isolates of Bacillus cereus and Bacillus thuringiensis revealed the existence of plasmids that share extensive sequence conservation with large segments of the anthrax virulence plasmids pXO1 and pXO2. We recently found that up to 15% of environmental isolates of B. cereus sensu lato group organisms contain pXO1-like or pXO2-like plasmids as defined on the basis of conserved replicon sequences.

    We are now sequencing 96 environmental isolates of B. cereus s. l. containing pXO1-like and/or pXO2-like plasmids in order to investigate the sequence conservation of the plasmid backbones, their functional modularity and the diversity of their “passenger” genes. We are also interested in what incongruence between the phylogenies of the plasmids and the chromosome of their respective bacterial hosts can tell us about the extent of past horizontal transfer.

    See project

Languages

  • English

    Native or bilingual proficiency

  • French

    Native or bilingual proficiency

  • Dutch

    Limited working proficiency

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