IMPC - International Mouse Phenotyping Consortium

The next MorphoPHEN –Infrafrontier Workshop in Mouse Pathobiology will take place in Barcelona 14-16 October 2024. For more information: https://lnkd.in/dKuSUf-Q INFRAFRONTIER #IMPC #Mouse #Genetics

We are proud to be part of this new paper, Improving Laboratory Animal Genetic Reporting: LAG-R Guidelines, now published in Nature Communications. https://lnkd.in/ey5QVedy This international effort is signed by leading experts, international societies, infrastructures and consortia. It provides a set of guidelines to support more complete documentation of the genetic make-up of animals of all species that are used in research, with the aim of bolstering reproducibility, reliability, and overall scientific rigour.

| 📚 new publication | Our partners from Mary Lyon Centre at MRC Harwell and Institut Clinique De La Souris ICS, have published "Improving laboratory animal genetic reporting: LAG-R guidelines" in Nature Communications. This work presents the Laboratory Animal Genetic Reporting (LAG-R) framework, a collection of guidelines to help the biomedical research community to overcome the reproducibility challenges faced in animal studies. These guidelines aim to enhance the transparency and completeness of genetic information reported in scientific publications involving laboratory animals. Many other INFRAFRONTIER partners and colleagues, including the IMPC - International Mouse Phenotyping Consortium, CELPHEDIA, and International Society for Transgenic Technologies, have also contributed to this publication. Overview and details 👉🏻 https://lnkd.in/dhpaDnA2

🚨 Data point release alert! Data release 21.1 is live on the IMPC web portal. With this point release we've updated late adult eye morphology analysis as well as parameter-image associations to allow more accurate descriptions of images. For more: https://lnkd.in/g43uZ9Wc #IMPC #mouse #genetics #phenotyping #data

"For the first time, researchers have mapped the entire network of blood vessels in the cortex of conscious mice, discovering rhythmic expansions and contractions of these vessels that create “waves” across the brain’s surface." Source: https://lnkd.in/g3wZdUvn

Are you interested in learning API? Would you like to learn how to obtain IMPC data by constructing simple Apache Solr API queries? If you're interested and you missed the IMPC Data API Workshop, the recording is now live on our YouTube Channel - IMPC Outreach! To access the recording and more: https://lnkd.in/ekK9Z2NH #IMPC #Biological #Data #API #Solr #mouse #genetics

#IMPCinResearch highlights research using IMPC resources with Rolfe et al. Biol Open (2023) 12 (2). Using mouse embryo microCT images generated by IMPC, freely available on the IMPC website, Rolfe et al. created deep learning tool to allow researchers to obtain estimates of multi-organ segmentation from fetal mouse scans. Atlas-based methods for segmentation are the current gold standard for segmentation analysis and this was used to generate a dataset for training the Mouse Embryo Multi-Organ Segmentation (MEMOS) tool for segmentation and quantification of anatomical structures from mouse embryo microCT images. They then validated the tool by analysing Cbx4 embryos with reported anatomical abnormalities. This tool allows analysis of large datasets with improved accuracy and efficiency and it is an open source for all researchers without requiring a prior coding knowledge. MEMOS is also customisable for specific segmentation tasks. Find the paper here: https://lnkd.in/gwABxdrJ Sara Rolfe Sophie Mei Lin Whikehart Murat Maga Seattle Children's #IMPC #MachineLearning #mouse #embryo #imagingdata #OpenScience

Did you miss the first ever IMPC Spring meeting in Cape Town in South Africa, titled ‘Beyond the Genome’? Don't worry, you can now access the recordings of the conference! For more: https://lnkd.in/eA4XEFWV

There are now over 7,000 publications citing the IMPC! These publications include studies utilising mouse mutant products created by IMPC centers and the freely accessible phenotyping data on the IMPC website. Don't forget to visit our website to discover IMPC data and products related to your genes of interest. For more: https://lnkd.in/eXFt3H3b #IMPC #publications #scientificresearch #mousegenetics

New MOBEs tech allows precise, efficient multi-mutation genome editing, revolutionizing mouse model research for complex diseases. MOBEs use RNA loops to target specific DNA sites, reducing errors and enhancing accuracy. Source: https://lnkd.in/djjkEWfv