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Role of IgA receptors in the pathogenesis of IgA nephropathy

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Abstract

Immunoglobulin A nephropathy (IgAN) or Berger’s disease is the most common form of primary glomerulonephritis in the world and one of the first causes of end-stage renal failure. IgAN is characterized by the accumulation of immune complexes containing polymeric IgA1 in mesangial areas. The pathogenesis of this disease involves the deposition of polymeric and hypogalactosylated IgA1 (Gd-IgA1) in the mesangium. Quantitative and structural changes of Gd-IgA1 play a key role in the development of the disease due to functional abnormalities of two IgA receptors: the FcαRI (CD89) expressed by blood myeloid cells and the transferrin receptor (CD71) on mesangial cells. Abnormal Gd-IgA1 induces release of soluble CD89, which participates in the formation of circulating IgA1 complexes. These complexes are trapped by CD71 that is overexpressed on mesangial cells in IgAN patients together with the crosslinking enzyme transglutaminase 2 allowing pathogenic IgA complex formation in situ and mesangial cell activation. A humanized mouse model expressing IgA1 and CD89 develops IgAN in a similar manner as patients. In this model, a food antigen, the gliadin, was shown to be crucial for circulating IgA1 complex formation and deposition, which could be prevented by a gluten-free diet. Identification of these new partners opens new therapeutic prospects for IgAN treatment.

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Acknowledgments

This work was supported by grants from ANR, FRM, INFLAMEX, INSERM, CNRS and Paris Diderot University. Sebastian M. Lechner PhD fellowship was supported by CORDDIM

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1149 Centre de Recherche sur l’Inflammation, Paris, France

    Sebastian M. Lechner, Christina Papista, Jonathan M. Chemouny, Laureline Berthelot & Renato C. Monteiro

  2. Université Paris Diderot, Sorbonne Paris Cité, Paris, France

    Sebastian M. Lechner, Christina Papista, Jonathan M. Chemouny, Laureline Berthelot & Renato C. Monteiro

  3. Inflamex Laboratory of Excellence Site Xavier Bichat, Paris, France

    Sebastian M. Lechner, Christina Papista, Jonathan M. Chemouny, Laureline Berthelot & Renato C. Monteiro

  4. CNRS ERL8252, Paris, France

    Sebastian M. Lechner, Christina Papista, Jonathan M. Chemouny, Laureline Berthelot & Renato C. Monteiro

  5. Service d’Immunologie, Assistance Publique de Paris, DHU Fire, Hôpital Bichat, Paris, France

    Renato C. Monteiro

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Lechner, S.M., Papista, C., Chemouny, J.M. et al. Role of IgA receptors in the pathogenesis of IgA nephropathy. J Nephrol 29, 5–11 (2016). https://doi.org/10.1007/s40620-015-0246-5

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