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Iodine Deficiency Is Higher in Morbid Obesity in Comparison with Late After Bariatric Surgery and Non-obese Women

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Abstract

Background

Iodine deficiency and obesity are worldwide-occurring health problems. Our purpose was to investigate the relationship between morbid obesity and iodine status, including subjects who lost weight after bariatric surgery.

Methods

Ninety morbidly obese women, 90 women with at least 18 months follow-up after bariatric surgery, and 45 healthy non-obese women were recruited. Urinary iodine concentration (UIC) was measured in a spot urinary sample and expressed as the iodine-to-creatinine ratio.

Results

Obese women showed a significantly lower UIC in comparison with non-obese women (96.6 (25.8–267.3) vs. 173.3 (47.0–493.6) μg/g; p < 0.001), with a lesser proportion of subjects with adequate iodine status (46.6 vs. 83.3 %, p < 0.001). The mean UIC significantly increased among women who underwent bariatric surgery before the collection of the urinary sample (96.6 (25.8–267.3) vs. 131.9 (62.9–496.4) μg/g; p < 0.001). No difference in UIC was detected between laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy. Univariate analysis showed that UIC negatively correlated with body mass index (BMI) (r = −0.278, p < 0.001) and positively with age (r = 0.206, p = 0.002). Finally, multiple linear regression analyses showed that BMI was independently associated with UIC (beta = −0.312, p < 0.001; R 2 = 0.166).

Conclusion

Obesity is an independent risk factor to iodine deficiency, almost in women. Whether more obese population needs to be considered as a vulnerable group and whether bariatric surgery can reverse iodine deficiency still remain to be elucidated.

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Acknowledgements

This study was supported by a grant from the Societat Catalana d’Endocrinologia i Nutrició (SCEN).

Conflict of Interest

The authors have no conflict of interest.

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Authors and Affiliations

  1. Endocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Av Rovira Roure, 80, 25198, Lleida, Spain

    Albert Lecube

  2. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Diabetes and Metabolism Research Unit, VHIR, Hospital Universitari Vall d’Hebron, Pg Vall d’Hebron 119-129, 08035, Barcelona, Spain

    Albert Lecube

  3. Endocrinology Department, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Pg Vall d’Hebron 119-129, 08035, Barcelona, Spain

    Carles Zafon, Adoración Gromaz & Frederic Tortosa

  4. Bariatric, Endocrinology, and Metabolic Surgery Unit, Surgery Department, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Pg Vall d’Hebron 119-129, 08035, Barcelona, Spain

    José Manuel Fort & Enric Caubet

  5. Bariatric, Endocrinology, and Metabolic Surgery Unit. Surgery Department, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Av Rovira Roure, 80, 25198, Lleida, Spain

    Juan Antonio Baena

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  1. Albert Lecube
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Correspondence to Albert Lecube.

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Lecube, A., Zafon, C., Gromaz, A. et al. Iodine Deficiency Is Higher in Morbid Obesity in Comparison with Late After Bariatric Surgery and Non-obese Women. OBES SURG 25, 85–89 (2015). https://doi.org/10.1007/s11695-014-1313-z

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  • DOI: https://doi.org/10.1007/s11695-014-1313-z

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