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Hope, despair and CRISPR — the race to save one woman’s life

Researchers in India fought to develop what could have been the first therapy to use gene-editing to halt a rare neurodegenerative disease. The efforts hold lessons for the messy state of modern drug development.
  1. Heidi Ledford
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Illustration of CRISPR–Cas9 and genetic code surrounded by family photos of Uditi and her parents.

CRISPR: Molekuul/SPL; Images: Rajeev and Sonam Saraf

When researcher Arkasubhra Ghosh finally met Uditi Saraf, he hoped that there was still a chance to save her.

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Nature 630, 284-288 (2024)

doi: https://doi.org/10.1038/d41586-024-01716-y

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