A laboratory mouse looks over the green gloved fingers of a technician

Scientists edit the genes of gut bacteria in living mice

A ‘base editor’ successfully modified a gene in more than 90% of Escherichia coli bacteria without unwanted side effects.

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  • We find that, in the quantum transition of Ising spin glass, the closing of the gap at the critical point can remain algebraic by restricting the symmetry of possible excitations, which is crucial for quantum annealing.

    • Massimo Bernaschi
    • Isidoro González-Adalid Pemartín
    • Giorgio Parisi
    ArticleOpen Access
  • The in-tissue architectures of β-amyloid and tau pathology in a postmortem Alzheimer’s disease donor brain are determined, showing fibril heterogeneity is spatially organized by subcellular location and suggesting applications to a broad range of neurodegenerative diseases.

    • Madeleine A. G. Gilbert
    • Nayab Fatima
    • René A. W. Frank
    ArticleOpen Access
  • The neural circuits in the hindbrain that link satiety and aversion are shown to be separate, raising the possibility of developing obesity drugs without the common side effects of nausea and vomiting.

    • Kuei-Pin Huang
    • Alisha A. Acosta
    • Amber L. Alhadeff
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  • The thermoelectric material Mg3Bi2 is shown to be ductile in single-crystal form along certain directions, with a room-temperature tensile strain of 100%, which is attributed to the gliding of dislocations.

    • Peng Zhao
    • Wenhua Xue
    • Qian Zhang
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Workers at the Jiangmen Underground Neutrino Observatory.

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