Cassandra Wigmore

Curious about the role of dysregulated #NLRP3 activation in disease pathology? Conventional methods aren’t always sufficient, but our latest #PromegaNotes article introduces innovative methods for in-depth insights into NLRP3 engagement and pathway inhibition in a cellular environment. https://bit.ly/3KL8GXY

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A team from ZHAW Zurich has showcased the transferability of CHO-cell-based mAb production processes from geometrically dissimilar stirred bioreactors for fed-batch and perfusion processes, the team has opened up new possibilities for cost savings and increased yields. Their study found that the high volumetric productivity in the perfusion processes can lead to cost savings, smaller bioreactor sizes, and maintained manufacturing capacity in production plants. Alternatively, yields could be increased by a factor of 2.8 to 3.2 while still using the same bioreactor size. We look forward to seeing how it will impact the future of antibody production. #biotech #antibodyproduction #research https://lnkd.in/eA9992FV

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Curious about valid statistical inference in the presence of patient heterogeneity? 🤔 Mark your calendars for the International Indian Statistical Association webinar on June 13th at 12 PM EST, where Devan Mehrotra, Vice President of Biostatistics at Merck, will discuss a recently published method (5-STAR) for analyzing treatment heterogeneity in survival data. Registration (free but required): https://lnkd.in/gHWNgw3w Paper: https://lnkd.in/gBypXW4K Code: https://lnkd.in/gXE4v_qy #Statistics #Biostatistics #DataScience #IISAWebinars

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Will we see you in Basel later this month? Come by Booth # 3 to speak with Nicolas Goffard, PhD and Rebecca Morris about maximising the potential of knowledge graphs and knowledge reviews for faster, more reliable decision-making. You can also register for our upcoming virtual knowledge graph free conference to see how leading biopharma like Boehringer Ingelheim, AstraZeneca and AbbVie are delivering knowledge graph value>> https://lnkd.in/eJXxq2Jv Oxford Global #OGDiscovery #Discovery24

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Speed, quality, and high titers. Usually you'd have to choose 2 of the 3. But not with us. Join Katherine Schewe in this webinar tomorrow (June 6), and discover the capabilities of our scalable, end-to-end VirusExpress® lentivirus platform. From plasmids to fill/finish, we can deliver real results. Make more and make it right. #genetherapy #viralvector #cdmo

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🤨 When free seems too good to be true, that’s because it usually is. Read our blog post to find out what free #pathwayanalysis tools can get you vs. premium ones like QIAGEN Ingenuity Pathway Analysis (#QIAGENIPA) – and whether the zero price tag is really worth it 👇

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Completing dosing of the final patient in the Karisma-Endoxifen study is an important milestone for Atossa and our robust (Z)-endoxifen development program, which includes five ongoing Phase 2 studies. We look forward to seeing the breast density reduction data in the coming months and sharing it with regulatory authorities as it will allow us to further progress plans for a potential Phase 3, registrational study. https://lnkd.in/e4ZEgpf7 #breastcancer

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Bioanalytics researchers in R&D/biopharma labs often struggle due to lack of integration of analytics tools with lab information systems. This makes the process inefficient, and vulnerable to errors. Our integrated assay analytics solutions built on tcgmcube is automating and streamlining this for some of the largest biopharma and biotech organizations! 🗓 Join us on 24th July for live demonstrations Register here ⬇ 🔷 Analytics for R&D labs https://lnkd.in/dQtMTCGG 🔷 Analytics for pharma manufacturing https://lnkd.in/dngpnY8n ✅Fetch data and write back analysis to LIMS ✅Generate calibration curve and back fit concentration for samples ✅Generate reports in compliance with regulations ✅Improved lab productivity with one workflow

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Enjoyed these publications on decentralised manufacturing authored by Domhnall Mc Gowan at Canadian Advanced Therapies Training Institute and Erika Francoeur at Boston Labs. Across four papers the authors discuss a variety of topics: 🔆 1️⃣ the evolution of decentralised manufacturing from centralised manufacturing and its importance in ubiquitous access of these therapeutics https://lnkd.in/e-hFUN9D 🌟 2️⃣ the utilisation of emerging technologies within #cellandgenetherapies such automated closed systems, highlighted especially by the Miltenyi Biotec Prodigy and Lonza's Cocoon. Equipment for tracking and transport logistics for chain of custody and chain of identification with systems such Vineti feature too. Not mentioned but Hataali is another interesting system as well. A quick overview of quality management, QC & Product testing also ensues. https://lnkd.in/ekm4iRC7 😎 3️⃣ This post couldn't be published without a discussion on #skills as well. In the third publication the authors interview three individuals across some of the challenges in developing a competent and sustainable workforce within the sector. https://lnkd.in/eYZVAGmU 📊 4️⃣ Last but not least in the fourth installment an overview of CAR-T bioprocessing is provided with considerations on how decentralised manufacturing could provide new paradigms in therapeutics accessibility. https://lnkd.in/ekSQ2GAE Craig Hasilo, Benjamin McLeod, Spencer Knight, Ry Leahy #skills, #communitybuilding, #bioprocessing, #manufacturing,

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🔬 Join our upcoming Spatial Biology Masterclass with OracleBio! 📅 Date & time: 15 May, Wednesday, 4 PM CET / 10 AM EST   Why attend? Delivering high-quality, quantitative data from digital pathology images is one of OracleBio’s core values. Tools such as Visiopharm enable OracleBio to achieve this by building robust, AI-powered image analysis workflows. In this masterclass, Karen McClymont and Gabriel Reines March will explore the QC strategies used to ensure accuracy and reproducibility in the following case studies: 💡 Case study 1: The creation of a pathologist-validated and scalable image analysis workflow for a retrospective clinical study involving over 2,200 IHC-stained colorectal polyp whole slide images. 💡 Case study 2: The use of Deep Learning apps to segment morphologically distinct cell subpopulations and the Phenoplex workflow to streamline the thresholding process for spatial phenotyping in multiplex IF-stained pre-clinical tissue.   Register now: https://hubs.ly/Q02qxpLS0   #VisiopharmSpatialSeries #Phenoplex

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😩 #Clinicalpathology labs: struggling to bring out the full potential of #molecularprofiling? Attend our panel discussion on May 16, 1:30 p.m. ET, in which clinicians from leading organizations will present real-world case studies of how they overcame these and other challenges to improve #precisionmedicine-based diagnostics ⬇️

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🙅 Don’t let variant identification errors slow your research down. Our top-of-the-line software #QCI IT and knowledge bases #COSMIC and #HGMD let you gain valuable and reliable insights into your disease-relevant variants without the struggle. Join our webinar tomorrow to learn more 👇

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I am excited to re-explore a deep dive into the challenges of drug discovery in Lifebit's blog post. Trace the evolution from target identification to the advancements of Drug Discovery 2.0, where AI and ML technologies optimise efficiency and efficacy. Uncover how these innovations reshape drug development, offering practical solutions to longstanding challenges. Our blog post is a comprehensive guide to the intricate drug development process, shedding light on the stringent standards and extensive clinical trials necessary to introduce new drugs to the market. Despite the significant challenges researchers face, such as cost and time constraints, innovative technologies are stepping up. From identifying potential drug targets to optimising lead candidates, each stage of the drug discovery process is meticulously examined, offering invaluable insights into this vital field. Be part of our exploration into the evolution of drug discovery and the transformative potential of Drug Discovery 2.0. With AI and ML driving progress, the future of drug development is more promising than ever: https://hubs.li/Q02CcFDX0 #DrugDiscovery #AIinHealthcare #Lifebit

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How OnPage benefits Elucigene Labs’ temperature monitoring system: 🧪Lab techs are immediately alerted and mobilized to unfavorable lab temperature changes 🥼Alert forwarding capabilities that enhance team collaboration 🔬Technicians have visibility into audit trails for time sensitive issues 📅On-call scheduling capabilities, so that alerts are always delivered to the right technician Learn more: https://lnkd.in/er-5BVrQ  #environmentalmonitoring #labtechnician #oncallscheduling #oncallcoordination #temperaturemonitoring

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A new blog posting titled "Evaluating R&D Productivity: A Deeper Dive" is now live at https://lnkd.in/gWc8kuFD and https://lnkd.in/gW7M_V4C. Key takeaways are: - Traditional R&D productivity measures lack the granularity needed to assess strategic shifts or technology adoption. - A microscopic approach, focusing on individual R&D components, can provide a more nuanced understanding of productivity trends. - Effectively utilizing R&D personnel's time, particularly for creative thinking and evaluation, is crucial for enhancing productivity. - Balancing communication methods and optimizing research meetings are essential for fostering efficient R&D processes.

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5000 #Gene Panel is Here! Grant Challenge from 10x Genomics! using #Xenium #Insitu Submission deadline: June 18, 2024 What would you do with more: more transcripts, more genes, more exploration, more single cell spatial insights? Now you can find out with a chance to win a 2-slide run of the upcoming #Xenium Prime 5K Pan Tissue and Pathways Panel* Fill out the form below and you’ll be provided with a link to submit a short abstract (< 500 words) describing how you’d use #Xenium Prime 5K. Two winners will be notified by July 9, 2024. *Winners who have access to a Xenium In Situ Analyzer will receive free reagents and consumables to run 2 slides with the Xenium Prime Pan Tissue & Pathways Panel (human or mouse) . Winners who do not have access to a Xenium instrument will receive a free Xenium Catalyst project with the Xenium Prime Pan Tissue & Pathways Panel (human or mouse) run on 2 slides. Don't know is you have access to an instrument? - Reach out to me! If you have any questions on the #grant please reach out to me or your loacl Xenium Specialist, Connor Noda! We look forward to hearing from you. click the link below to submit! https://lnkd.in/gM67MExR

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This is truly one-of-a-kind collaboration and partnership designed to bring resources to communities who have not gotten a lot of support/attention in the past. There is using FIGG/DNA on a case-by-case basis, and then there is the creation of a whole lab dedicated to certain causes. It's a true honor to work for a company that is contributing to both... Haley Omeasoo, MA University of Montana #MMIP #sugarland95DNAproject #FIGG #geneticgenealogy #forensicDNA https://lnkd.in/eCTvacZU

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