Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Nov 11;11(12):823-36.
doi: 10.1038/nri3084.

Towards a systems understanding of MHC class I and MHC class II antigen presentation

Jacques Neefjes  1 , Marlieke L M Jongsma, Petra Paul, Oddmund Bakke
Affiliations
Review

Towards a systems understanding of MHC class I and MHC class II antigen presentation

Jacques Neefjes et al. Nat Rev Immunol. .

Abstract

The molecular details of antigen processing and presentation by MHC class I and class II molecules have been studied extensively for almost three decades. Although the basic principles of these processes were laid out approximately 10 years ago, the recent years have revealed many details and provided new insights into their control and specificity. MHC molecules use various biochemical reactions to achieve successful presentation of antigenic fragments to the immune system. Here we present a timely evaluation of the biology of antigen presentation and a survey of issues that are considered unresolved. The continuing flow of new details into our understanding of the biology of MHC class I and class II antigen presentation builds a system involving several cell biological processes, which is discussed in this Review.

PubMed Disclaimer

References

    1. J Virol. 2007 Jul;81(13):7220-9 - PubMed
    1. Eur J Immunol. 1988 May;18(5):801-10 - PubMed
    1. Immunity. 1997 Dec;7(6):861-71 - PubMed
    1. Nature. 2011 Jul 10;475(7356):394-7 - PubMed
    1. J Cell Biol. 2001 Oct 1;155(1):53-63 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources