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. 2004 Feb;72(2):1192-4.
doi: 10.1128/IAI.72.2.1192-1194.2004.

Hydrogen peroxide-mediated killing of Caenorhabditis elegans: a common feature of different streptococcal species

Maike Bolm  1 , Wouter T M Jansen, Ralf Schnabel, Gursharan S Chhatwal
Affiliations

Hydrogen peroxide-mediated killing of Caenorhabditis elegans: a common feature of different streptococcal species

Maike Bolm et al. Infect Immun. 2004 Feb.

Abstract

Recently, we reported that Streptococcus pyogenes kills Caenorhabditis elegans by the use of hydrogen peroxide (H2O2). Here we show that diverse streptococcal species cause death of C. elegans larvae in proportion to the level of H2O2 produced. H2O2 may mask the effects of other pathogenicity factors of catalase-negative bacteria in the C. elegans infection model.

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Figures

FIG. 1.
FIG. 1.
H2O2 production and nematode killing by S. pneumoniae strain ATCC 6319. Results are mean values from two representative experiments. H2O2 production is indicated by triangular symbols, nematode killing without catalase is shown with closed square symbols, and killing with catalase is depicted with open square symbols.
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References

    1. AlonsoDeVelasco, E., A. F. Verheul, J. Verhoef, and H. Snippe. 1995. Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines. Microbiol. Rev. 59:591-603. - PMC - PubMed
    1. Braun, J. S., J. E. Sublett, D. Freyer, T. J. Mitchell, J. L. Cleveland, E. I. Tuomanen, and J. R. Weber. 2002. Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis. J. Clin. Investig. 109:19-27. - PMC - PubMed
    1. Brenner, S. 1974. The genetics of Caenorhabditis elegans. Genetics 77:71-94. - PMC - PubMed
    1. Duane, P. G., J. B. Rubins, H. R. Weisel, and E. N. Janoff. 1993. Identification of hydrogen peroxide as a Streptococcus pneumoniae toxin for rat alveolar epithelial cells. Infect. Immun. 61:4392-4397. - PMC - PubMed
    1. Efstratiou, A. 1997. Pyogenic streptococci of Lancefield groups C and G as pathogens in man. Soc. Appl. Bacteriol. Symp. Ser. 26:72S-79S. - PubMed

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