Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Sep;6(3):180-5.
doi: 10.1093/bfgp/elm022. Epub 2007 Oct 29.

EUCOMM--the European conditional mouse mutagenesis program

Roland H Friedel  1 , Claudia Seisenberger, Cornelia Kaloff, Wolfgang Wurst
Affiliations

EUCOMM--the European conditional mouse mutagenesis program

Roland H Friedel et al. Brief Funct Genomic Proteomic. 2007 Sep.

Abstract

Functional analysis of the mammalian genome is an enormous challenge for biomedical scientists. To facilitate this endeavour, the European Conditional Mouse Mutagenesis Program (EUCOMM) aims at generating up to 12 000 mutations by gene trapping and up to 8000 mutations by gene targeting in mouse embryonic stem (ES) cells. These mutations can be rendered into conditional alleles, allowing Cre recombinase-mediated disruption of gene function in a time- and tissue-specific manner. Furthermore, the EUCOMM program will generate up to 320 mouse lines from the EUCOMM resource and up to 20 new Cre driver mouse lines. The EUCOMM resource of vectors, mutant ES cell lines and mutant mice will be openly available to the scientific community. EUCOMM will be one of the cornerstones of an international effort to create a global mouse mutant resource.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • The New Way to Define Key Oncogenic Drivers of Small Cell Lung Cancer.
    Kim KB. Kim KB. Dev Reprod. 2023 Apr;27(1):1-7. doi: 10.12717/DR.2023.27.1.1. Epub 2023 Mar 31. Dev Reprod. 2023. PMID: 38075442 Free PMC article.
  • Transgenesis and Genome Engineering: A Historical Review.
    Montoliu L. Montoliu L. Methods Mol Biol. 2023;2631:1-32. doi: 10.1007/978-1-0716-2990-1_1. Methods Mol Biol. 2023. PMID: 36995662
  • Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
    Sheppard SE, Bryant L, Wickramasekara RN, Vaccaro C, Robertson B, Hallgren J, Hulen J, Watson CJ, Faundes V, Duffourd Y, Lee P, Simon MC, de la Cruz X, Padilla N, Flores-Mendez M, Akizu N, Smiler J, Pellegrino Da Silva R, Li D, March M, Diaz-Rosado A, Peixoto de Barcelos I, Choa ZX, Lim CY, Dubourg C, Journel H, Demurger F, Mulhern M, Akman C, Lippa N, Andrews M, Baldridge D, Constantino J, van Haeringen A, Snoeck-Streef I, Chow P, Hing A, Graham JM Jr, Au M, Faivre L, Shen W, Mao R, Palumbos J, Viskochil D, Gahl W, Tifft C, Macnamara E, Hauser N, Miller R, Maffeo J, Afenjar A, Doummar D, Keren B, Arn P, Macklin-Mantia S, Meerschaut I, Callewaert B, Reis A, Zweier C, Brewer C, Saggar A, Smeland MF, Kumar A, Elmslie F, Deshpande C, Nizon M, Cogne B, van Ierland Y, Wilke M, van Slegtenhorst M, Koudijs S, Chen JY, Dredge D, Pier D, Wortmann S, Kamsteeg EJ, Koch J, Haynes D, Pollack L, Titheradge H, Ranguin K, Denommé-Pichon AS, Weber S, Pérez de la Fuente R, Sánchez Del Pozo J, Lezana Rosales JM, Joset P, Steindl K, Rauch A, Mei D, Mari F, Guerrini R, Lespinasse J, Tran Mau-Them F, Philippe C, Dauriat B, Raymond L, Moutton S, Cueto-González AM, Tan TY, Mignot C, Grotto S, Renaldo F, … See abstract for full author list ➔ Sheppard SE, et al. Sci Adv. 2023 Mar 10;9(10):eade1463. doi: 10.1126/sciadv.ade1463. Epub 2023 Mar 10. Sci Adv. 2023. PMID: 36897941 Free PMC article.
  • The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse.
    Danielli S, Ma Z, Pantazi E, Kumar A, Demarco B, Fischer FA, Paudel U, Weissenrieder J, Lee RJ, Joyce S, Foskett JK, Bezbradica JS. Danielli S, et al. EMBO J. 2023 Apr 3;42(7):e111450. doi: 10.15252/embj.2022111450. Epub 2023 Mar 2. EMBO J. 2023. PMID: 36861806 Free PMC article.
  • Genome Editing and Myocardial Development.
    Turan S, Chaillet JR, Stapleton MC, Wu YL. Turan S, et al. Adv Exp Med Biol. 2023;1396:53-73. doi: 10.1007/978-981-19-5642-3_4. Adv Exp Med Biol. 2023. PMID: 36454459 Review.
See all "Cited by" articles

LinkOut - more resources