A mouse for all reasons
- PMID: 17218247
- DOI: 10.1016/j.cell.2006.12.018
A mouse for all reasons
Abstract
Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of gene trapping and gene targeting in mouse embryonic stem (ES) cells. Although the current emphasis is on production of this valuable resource, there are significant efforts to facilitate program coordination, to enhance the availability of this resource, and to plan for future efforts in mouse genetics research.
Comment in
-
A new partner for the international knockout mouse consortium.Cell. 2007 Apr 20;129(2):235. doi: 10.1016/j.cell.2007.04.007. Cell. 2007. PMID: 17448981 No abstract available.
Similar articles
-
A review of current large-scale mouse knockout efforts.Genesis. 2010 Feb;48(2):73-85. doi: 10.1002/dvg.20594. Genesis. 2010. PMID: 20095055 Review.
-
Gene trapping in embryonic stem cells.Methods Enzymol. 2006;420:136-62. doi: 10.1016/S0076-6879(06)20008-9. Methods Enzymol. 2006. PMID: 17161697
-
EUCOMM--the European conditional mouse mutagenesis program.Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5. doi: 10.1093/bfgp/elm022. Epub 2007 Oct 29. Brief Funct Genomic Proteomic. 2007. PMID: 17967808
-
Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells.Nucleic Acids Res. 2006;34(21):e147. doi: 10.1093/nar/gkl896. Epub 2006 Nov 16. Nucleic Acids Res. 2006. PMID: 17142234 Free PMC article.
-
Gene trap mutagenesis.Handb Exp Pharmacol. 2007;(178):129-47. doi: 10.1007/978-3-540-35109-2_6. Handb Exp Pharmacol. 2007. PMID: 17203654 Review.
Cited by
-
Knockout mice with pituitary malformations help identify human cases of hypopituitarism.Genome Med. 2024 May 31;16(1):75. doi: 10.1186/s13073-024-01347-y. Genome Med. 2024. PMID: 38822427 Free PMC article.
-
Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.PLoS Genet. 2024 Apr 10;20(4):e1011228. doi: 10.1371/journal.pgen.1011228. eCollection 2024 Apr. PLoS Genet. 2024. PMID: 38598567 Free PMC article.
-
Discovery and validation of genes driving drug-intake and related behavioral traits in mice.Genes Brain Behav. 2024 Jan 2;23(1):e12875. doi: 10.1111/gbb.12875. Online ahead of print. Genes Brain Behav. 2024. PMID: 38164795 Free PMC article.
-
Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD.Front Cell Dev Biol. 2023 Jun 16;11:1208279. doi: 10.3389/fcell.2023.1208279. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37397253 Free PMC article.
-
A method for generating user-defined circular single-stranded DNA from plasmid DNA using Golden Gate intramolecular ligation.Biotechnol Bioeng. 2023 Oct;120(10):3057-3066. doi: 10.1002/bit.28471. Epub 2023 Jun 27. Biotechnol Bioeng. 2023. PMID: 37366288
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources