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CRISPRi knockdown of essential genes combined with TnSeq of non-essential genes yields a high-throughput method for bacterial genetic interaction mapping.
A systematic implementation of six efficiency optimizations for prime editing led to high levels of functional correction, in airway epithelial cells, of the predominant mutation that causes cystic fibrosis.
Holo-2bRAD allows cost-effective and stable tracking of hologenome dynamics in marine invertebrates, also for difficult samples. It was used to identify two host SNPs and a change of core microbial species in mass mortality events of bivalve larvae.
This work presents ORFtag that enables proteome-wide functional screens by tagging and overexpression of endogenously encoded proteins via randomly integrated cassettes.
It’s not just people with ultra-rare disorders who could benefit from hyper-personalized therapies. Scientists and regulators must work together to ensure the benefits are spread.
Researchers in India fought to develop what could have been the first therapy to use gene-editing to halt a rare neurodegenerative disease. The efforts hold lessons for the messy state of modern drug development.