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Diseases are abnormal conditions that have a specific set of signs and symptoms. Diseases can have an external cause, such as an infection, or an internal cause, such as autoimmune diseases.
Analysis of a dataset on zoonotic diseases such as Ebola and avian flu reveals that although zoonotic outbreaks can reduce the incidence of civil war, they increase social conflicts that involve civil defence groups, vigilantes and other identity militias.
For patients with shortness of breath, a new, simplified screening tool — relying only on basic clinical information — can estimate the probability of heart failure with preserved ejection fraction, providing the opportunity for improved detection in non-specialist settings.
Nearly 50% of the sequence of mammalian genomes is derived from mobile elements that inserted into the genome over millions of years of evolution. A recent mobile element insertion, found only in some individuals with European genetic ancestry, contributes to decreased skin pigmentation and increased sunburn frequency and skin cancer risk.
Vinuesa et al. identify patients with systemic autoimmunity and a TNIP1 variant that result in dysregulated B cell function. Mice with the orthologous Tnip1 mutation develop spontaneous autoimmunity associated with impaired mitophagy and autophagic silencing of proteins downstream of Toll-like receptor 7 signaling.
This PrimeView highlights the pathophysiological mechanisms of von Willebrand disease, and summarizes the epidemiology, diagnosis, management and quality of life of this disorder. It accompanies the Primer article on this topic by Seidizadeh et al.
A natural experiment of over 200,000 people who received a shingles vaccine revealed that the recombinant vaccine is associated with lower risk of dementia than the live vaccine, within 6 years of vaccination
Analysis of a dataset on zoonotic diseases such as Ebola and avian flu reveals that although zoonotic outbreaks can reduce the incidence of civil war, they increase social conflicts that involve civil defence groups, vigilantes and other identity militias.
For patients with shortness of breath, a new, simplified screening tool — relying only on basic clinical information — can estimate the probability of heart failure with preserved ejection fraction, providing the opportunity for improved detection in non-specialist settings.
Nearly 50% of the sequence of mammalian genomes is derived from mobile elements that inserted into the genome over millions of years of evolution. A recent mobile element insertion, found only in some individuals with European genetic ancestry, contributes to decreased skin pigmentation and increased sunburn frequency and skin cancer risk.
We present a multi-omic map of the human kidney in health and disease, using single-cell RNA, single-nuclei RNA, single-nuclei assay for transposase-accessible chromatin sequencing, spot-based and single-cell spatial transcriptomics. This comprehensive approach enables an in-depth understanding of the microenvironments in the diseased kidney.