Volume 21

  • No. 7 July 2024

    Tissue histology in 3D

    c-Fos+ neuronal mapping of whole mouse brains using DELiVR reveals cancer-induced brain activity changes.

    See Kaltenecker et al.

  • No. 6 June 2024

    Mapping white matter in chimpanzee

    Transverse view of a whole-brain tract-density reconstruction of white matter pathways in the chimpanzee brain. Color indicates tissue orientation and brightness encodes density of reconstructed fiber streamlines.

    See Eichner et al.

  • No. 5 May 2024

    Focus on methods for immunology

    A scanning electron microscope image captures the dynamic interplay between a CD19-hexapod biomimetic antigen-presenting structure and an anti-CD19 CAR-T cell.

    See Huang et al.

  • No. 4 April 2024

    Advanced nanopore-based peptide sequencing

    Peptide sequencing by nanopore: a crow drops grapes into a pitcher with a narrow neck, representing the cleavage of a peptide into amino acids and their subsequent detection by a modified nanopore.

    See Zhang et al.

  • No. 3 March 2024

    Brighter autonomous bioluminescence

    Autonomously glowing Arabidopsis thaliana plants express an improved version of the fungal bioluminescence pathway.

    See Shakhova et al.

  • No. 2 February 2024

    Smart lattice light-sheet microscopy

    Smart lattice light-sheet microscopy captures rare cellular events. The image shows immune synapses formed between cytotoxic T lymphocytes (cyan) and tumor cells (magenta) within a population of cultured cells. Cytotoxic granules are shown in yellow.

    See Shi et al.

  • No. 1 January 2024

    Integrated protein structure modeling for cryo-EM

    DeepMainmast builds structures of protein complexes from cryo-electron microscopy maps. It uses deep learning to identify key atom positions in the density, which are then connected to build fragment structures. Fragments are combined into a full structure, which is refined to atomic detail.

    See Terashi et al.