A fundamental mechanism for information processing in the brain is electrical activity. However, observing such activity at the single-cell level is challenging. We have developed an optical microscope that combines the advantages of targeted illumination and confocal gating to enable kilohertz-rate voltage imaging across large fields of view in thick tissue.
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References
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This is a summary of: Xiao, S. et al. Large-scale deep tissue voltage imaging with targeted-illumination confocal microscopy. Nat. Methods https://doi.org/10.1038/s41592-024-02275-w (2024).
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Targeted illumination confocal microscopy enables in vivo voltage imaging in thick tissue. Nat Methods 21, 948–949 (2024). https://doi.org/10.1038/s41592-024-02276-9
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DOI: https://doi.org/10.1038/s41592-024-02276-9
